LDL-Cholesterol assay

Description

Intended Use

For the quantitative in vitro determination of LDL Cholesterol in serum or plasma. This product is suitable for automated, semi-automated and manual use.

Clinical Significance

Low Density Lipoproteins (LDL) are synthesised in the liver by the action of various Lipolytic enzymes on triglyceride rich Very Low Density Lipoproteins (VLDLs). Specific LDL receptors exist to facilitate the elimination of LDL from plasma by liver parenchymal cells. It has been shown that most of the cholesterol stored in atherosclerotic plaques originates from LDL. For this reason the LDL-Cholesterol concentration is considered to be the most important clinical predictor, of all single parameters, with respect to coronary atherosclerosis.

Accurate measurement of LDL-Cholesterol is of vital importance in therapies which focus on lipid reduction to prevent atherosclerosis or reduce its progress and to avoid plaque rupture.

In this diagnostic test kit an elimination method for the measurement of LDL-Cholesterol, without sample pre-treatment, is presented which correlates well with precipitation methods.