CK-MB assay

Description

Intended Use

For the quantitative in vitro determination of CK-MB in serum or plasma. This product is suitable for automated, semi-automated and manual use.

Clinical Significance

Creatine Kinase (CK) is internationally accepted as a sensitive and specific indicator of acute myocardial infarction (AMI). There are 3 iso-enzymes of CK, CK-MM, CK-MB and CK-BB. CK-BB is produced by the brain in very small insignificant amounts. CK-MM is produced by the skeletal and heart tissue and CK-MB is produced by the heart muscle. In the vast majority of cases, the CK activity rises within 6 hours of an acute infarction. After about 20 hours, maximum values are observed. The CK activity generally returns to normal between the fourth and fifth day post- infarction.