Ammonia (NH3) assay

Description

Intended Use

For the quantitative in vitro determination of Ammonia in plasma. This product is suitable for automated, semi-automated and manual use.

Clinical Significance

The major source of circulating ammonia is the GI tract. Under normal conditions, ammonia is metabolised to urea by liver enzymes. Several diseases, both inherited and acquired, cause elevated ammonia (hyperammonemia). The inherited deficiencies of urea cycle enzymes are the major cause of hyperammonemia in infants. The acquired hyperammonemia diseases are caused by liver disease, renal failure and Reye?s Syndrome. Elevated ammonia is toxic to the central nervous system.