The Randox Toxicology Tramadol ELISA provides a fast, reliable method to detect the presence of Tramadol.
Tramadol is a synthetic opioid-receptor agonist that has been used clinically as a narcotic analgesic since 1977. Tramadol also inhibits the reuptake of monoamines such as norepinephrine and serotonin, which enhances its analgesic effect. O-desmethyltramadol has 2-4 times the analgesic efficacy of the parent drug.
In all body tissues and blood, the drug concentration is greater than the N-desmethyl and O-desmethyltramadol metabolites, and O-desmethyltramadol is always greater in concentration than the N-desmethyl metabolite. There are numerous reports of tramadol toxicity and abuse. Overdoses of ?500 mg may cause agitation, hypertension, tachycardia and seizures, while doses >800 mg may cause coma and respiratory depression.