TxBCardio assay

For the quantitative in vitro determination of 11dhTxB2 in urine. This product is suitable for automated, semi-automated and manual use.

SKU: TBX2759 Category: Method: Immunoturbidimetric Format: Liquid ready-to-use Size: R1 1 x 9ml, R2 1 x 4.7ml Assay Range: 400 - 6000pg/ml Working Stability: Stable to expiry when stored at +2 to +8°C Available Applications: Available for wide range of instruments Tags: , , , , , ,

$2,726.46

Out of stock

Description

Intended Use

For the quantitative in vitro determination of 11dhTxB2 in urine. This product is suitable for automated, semi-automated and manual use.

Clinical Significance

Activated and aggregated platelets play a key role in the pathogenesis of cardiovascular disease. Activated platelets produce Thromboxane A2 (TxA2), a potent vasoconstrictor and inducer of platelet aggregation. TxA2 is generated by Thromboxane synthase from molecules derived from arachidonic acid by cyclooxygenase-1 (COX-1). TxA2 has a short half-life in plasma and is rapidly hydrolysed to Thromboxane B2 (TxB2). TxB2, in turn, is metabolised to 11-Dehydro Thromboxane B2 (11dhTxB2), I1-Dehydro dinor Thromboxane B2 (11dh2,3DTxB2, a truncated form of 11dhTxB2), and a number of other minor TxB2 metabolites which are excreted by the kidney. Thus, 11dhTxB2 is a stable metabolite of TxA2 and an in vivo indicator of platelet activity.
Acetylsalicylic acid (ASA) has been known for many years to have anti-platelet activity.8 ASA functions by acetylating and irreversibly inhibiting COX-1, thus inhibiting the production of TxA2 and its metabolites. Low dose ASA blocks more than 95% of platelet COX-1 activity. The measurement of stable metabolites of TxA2, such as urinary 11dhTxB2, is a means of quantitating TxA2 production in vivo and thus a direct way to analyse ASA’s effect post ingestion. The TxBCardio™ Test may determine if the ASA ingested by an individual is inhibiting cyclooxygenase activity through the measurement of 11dhTxB2. ASA is available under multiple brand names and/or in several different forms including Bayer Aspirin®.

Product Availability

Product Availability

Product availability may vary from country to country. Some products may be for research use only. For more information on product availability please contact marketing@randox.com