TxBCardio assay

For the quantitative in vitro determination of 11dhTxB2 in urine. This product is suitable for automated, semi-automated and manual use.

SKU: TBX2759 Category: Method: Immunoturbidimetric Format: Liquid ready-to-use Size: R1 1 x 9ml, R2 1 x 4.7ml Assay Range: 400 - 6000pg/ml Working Stability: Stable to expiry when stored at +2 to +8℃ Available Applications: Available for wide range of instruments Tags: , , , , , ,

$2,798.84

In stock

Quantity

$2,798.84

In stock

Description

Intended Use

For the quantitative in vitro determination of 11dhTxB2 in urine. This product is suitable for automated, semi-automated and manual use.

Clinical Significance

Activated and aggregated platelets play a key role in the pathogenesis of cardiovascular disease. Activated platelets produce Thromboxane A2 (TxA2), a potent vasoconstrictor and inducer of platelet aggregation. TxA2 is generated by Thromboxane synthase from molecules derived from arachidonic acid by cyclooxygenase-1 (COX-1). TxA2 has a short half-life in plasma and is rapidly hydrolysed to Thromboxane B2 (TxB2). TxB2, in turn, is metabolised to 11-Dehydro Thromboxane B2 (11dhTxB2), I1-Dehydro dinor Thromboxane B2 (11dh2,3DTxB2, a truncated form of 11dhTxB2), and a number of other minor TxB2 metabolites which are excreted by the kidney. Thus, 11dhTxB2 is a stable metabolite of TxA2 and an in vivo indicator of platelet activity.
Acetylsalicylic acid (ASA) has been known for many years to have anti-platelet activity.8 ASA functions by acetylating and irreversibly inhibiting COX-1, thus inhibiting the production of TxA2 and its metabolites. Low dose ASA blocks more than 95% of platelet COX-1 activity. The measurement of stable metabolites of TxA2, such as urinary 11dhTxB2, is a means of quantitating TxA2 production in vivo and thus a direct way to analyse ASA?s effect post ingestion. The TxBCardio? Test may determine if the ASA ingested by an individual is inhibiting cyclooxygenase activity through the measurement of 11dhTxB2. ASA is available under multiple brand names and/or in several different forms including Bayer Aspirin?.