H-FABP assay

For the quantitative in vitro determination of H-FABP in serum or plasma. This product is suitable for automated, semi-automated and manual use.

SKU: FB4025 Categories: , , , , , , , , Method: IMMUNOTURBIDIMETRIC Format: Format goes here Size: R1 1x19ml, R2 1x7ml Assay Range: Assay Range goes here Working Stability: Working Stability goes here Available Applications: RX daytona, RX daytona+, RX imola, RX monaco Tags: , , , , ,

$2,135.43

In stock

Quantity

$2,135.43

In stock

Description

Intended Use

For the quantitative in vitro determination of H-FABP in serum or plasma. This product is suitable for automated, semi-automated and manual use.

Clinical Significance

Heart–type Fatty Acid Binding Protein (H-FABP) is a low molecular-weight (15kD) cytoplasmic protein that is involved in the intracellular uptake and buffering of free fatty acids in the myocardium. The combination of its low molecular weight and cytoplasmic location enables H-FABP to be a highly sensitive early rise marker of acute coronary syndrome, detectable as early as 30 minutes following the onset of an ischemic episode.

 

H-FABP concentrations peak at approximately 6-8 hours and return to normal within approximately 24-30 hours. Although H-FABP has similar release kinetics to Myoglobin, it is approximately 15-20 times more cardiac specific, hence making it a more effective marker of myocardial injury.

 

Using a combination of H-FABP and Troponin has been shown to significantly improve the diagnostic sensitivity for MI/ACS during the early hours after symptom onset (at presentation,10 <4 hours11 or <6 hours12) compared to using Troponin alone. Prognostically, a number of large trials have illustrated the value of H-FABP in stratifying long-term ACS risk in both Troponin positive and Troponin negative patients. H-FABP has also been shown to be incrementally additive to Troponin, diagnostically and prognostically, even when a highly sensitive Troponin assay is used10.

 

In addition to ACS, H-FABP has been found to be clinically useful in a range of other applications, such as pulmonary embolism (PE)17, coronary artery bypass surgery (CABG)18 and cerebrovascular disease.

Product Availability

Product Availability

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