EDDP assay

For the quantitative in vitro determination of EDDP in urine. This product is suitable for automated, semi-automated and manual use.

SKU: DA4013 Categories: , , , , , , , Method: Homogeneous enzyme immunoassay Format: Liquid Size: R1 2 x 16.9ml, R2 2 x 8ml Assay Range: Refer to kit insert Working Stability: Stable up to the expiry date when stored at +2 to +8°C Available Applications: RX daytona, RX daytona+, RX imola, RX monaco Tags: , , , ,

$2,048.64

Out of stock

Description

Intended Use

For the quantitative in vitro determination of EDDP in urine. This product is suitable for automated, semi-automated and manual use.

Clinical Significance

Methadone is a synthetic diphenylheptanonylamine opioid that has similar analgesic activity and potency as morphine when administered parenterally. However unlike morphine, it reliably retains its effectiveness when given orally, and tolerance and physical dependency develop slowly. Although methadone is prescribed to relieve chronic pain, its primary medical application is the detoxification and/or maintenance treatment of narcotic or heroin addiction. The abuse potential of methadone is comparable to that of morphine due to its resembling pharmacological activity. Methadone is readily absorbed from gastrointestinal tract when ingested, and metabolised extensively in the liver. Initial N-demethylation results in normethadone metabolite, which rapidly undergoes cyclsation followed by dehydration to form the 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine, commonly known as EDDP. Further N-demethylation yields a secondary metabolite, the 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP). The metabolites are secreted in urine or bile along with unchanged drug. Current methadone immunoassays can detect only the parent drug and are subject to “false positives” from adulteration of samples for drug of abuse testing, or “false negatives” for methadone compliance testing urine samples from fast metabolisers. As a result, confirmation of the presence of EDDP by LC or GC is often required. EDDP immunoassay detection will make compliance testing easy, and also rule out the possibility adulteration of unsupervised sample collections.

Available Applications

  • RX daytona
  • RX daytona+
  • RX imola
  • RX monaco

Product Availability

Product Availability

Product availability may vary from country to country