B? Microglobulin assay

For the quantitative in vitro determination of B2M in serum. This product is suitable for automated, semi-automated and manual use.

SKU: BM8016 Categories: , , Method: Immunoturbidimetric Format: Liquid Size: R1 2x11.6ml, R2 2x4.9ml Assay Range: Measuring range 0.476 to 20.4 mg/l Working Stability: To expiry at +2 to +8°C Available Applications: Applications are available for a wide range of instruments Tags: ,

$1,406.68

Out of stock

Description

Intended Use

For the quantitative in vitro determination of B2M in serum. This product is suitable for automated, semi-automated and manual use.

Clinical Significance

B2Microglobulin is a low molecular weight protein (11800D) found of the surface of all cells except erythrocytes and the trophoblastic layer of the placenta. It is a constituent of the light chain of human histocompatibility antigens HLA, A, B and C. B2M is found on T and B cells and in tumor associated transplantation antigens. B2M may control the expression of antigens on the cell surface and their biosynthesis.

In healthy individuals, B2M is synthesized at a rate of
9 mg/hours and is eliminated mostly by the kidneys (10).

In AIDS serum, B2M is an accurate predictor of the progression of the disease in HIV infected groups including haemophiliacs. Levels above 5 mg/l indicate rapid progression and poor prognosis.

In various mylomas, 2M levels have been related to tumor mass, prognosis, disease activity and effectiveness of treatment. Levels below 4 mg/l indicate better prognosis than levels above 20 mg/l.

Product Availability

Product Availability

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